Caprine goat5/1/2023 Principal components analysis (PCA) shows that the three bezoar populations, which were collected in the Middle East ( Fig. caucasica), which are referred to as the ibex-like species ( 17), fall exclusively in another branch divergent from bezoar-goat ( Fig. S4), confirming that modern domestic goats are the descendants of bezoar-like ancestors ( 16). Tracking these archaeologically cryptic evolutionary transformations provides new insights into the mechanisms of animal domestication.Ī whole-genome neighbor-joining phylogenetic tree reveals that all domestic goats form a monophyletic sister lineage to bezoars ( Fig. The selected alleles at these two loci emerged in domestic goats at least 72 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Another locus with a strong signal of selection may be related to behavior. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. One introgressed locus with a strong signature of selection harbors the MUC6 gene, which encodes a gastrointestinally secreted mucin. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Bradley, Rasmus Heller, Guojie Zhang, Wen Wang, Yulin Chen, and Yu Jiang Show Fewer Sonstegard, Ali Esmailizadeh, Wenguang Zhang, Tingting Zhang, Yangbin Xu, Naiyi Xu, Yi Yang, Jianlin Han, Lei Chen, Joséphine Lesur, Kevin G. Zhuqing Zheng, Xihong Wang, Ming Li, Yunjia Li, Zhirui Yang, Xiaolong Wang, Xiangyu Pan, … Show All …, Mian Gong, Yu Zhang, Yingwei Guo, Yu Wang, Jing Liu, Yudong Cai, Qiuming Chen, Moses Okpeku, Licia Colli, Dawei Cai, Kun Wang, Shisheng Huang, Tad S.
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